ENMD2076 cas:934353-76-1

ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM,25-fold selective for Aurora A than over Aurora B and less potent to RET,SRC,NTRK1/TRKA,CSF1R/FMS,VEGFR2/KDR,FGFR and PDGFRα.ENMD-2076 inhibits the growth of a wide range of human solid tumor and hematopoietic cancer cell lines with IC50 from 0.025 to 0.7 μM,which induces apoptosis and G2/M phase arrest.

msds---ENMD2076